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Hamada Sandwich Technique


Introducing the BioXclude® 'Sandwich' Technique - A new powerful regenerative therapy for enhanced healing! This technique involves applying dehydrated deepithelialized amnion-chorion allograft membrane (BioXclude®) directly onto the debrided root surface(s), filling the defect with bone graft, followed by placement of a second piece of BioXclude as the barrier membrane.

New Powerful Regenerative Therapy for Enhanced Periodontal Healing



The idea to cover root surfaces with BioXclude came while listening to Dr. Paul Rosen, where he dripped recombinant human platelet-derived growth factor beta (rhPDGFbb) onto root surfaces prior to guided tissue regeneration. Most importantly, unlike rhPDGFbb, BioXclude delivers a sustained release of a wide variety of growth factors throughout resorption.

BioXclude Delivers Sustained Release of a Wide Variety of Growth Factors Throughout Resorption

Root Surface Applications of BioXclude Membrane
(Biologically-Active and Antimicrobial)


(After 24 Hours)

I want to publicly acknowledge and congratulate Dr. Yusuke Hamada for presenting the BioXclude 'Sandwich' Technique for the first time at the recent International Symposium on Periodontics and Restorative Dentistry meeting in Boston and continue to applaud his willingness to explore new ways to use regenerative materials for improved outcomes. Click here to view Dr. Hamada's poster from ISPRD.

Sustained Release Throughout Resorption

Results: Total of 6 teeth currently analyzed. (n=6)
Clinical Parameters at Baseline and 6 Months (Mean±SD)

 BaselinePost-OpChanges
PD (mm)7.67±1.123.44±0.734.22 ±0.97*
GR (mm)0.44±1.012.22±1.561.78±1.79*
CAL (mm)8.11±1.625.67±1.732.44±2.24*
(* P<0.05)
PD= Probing Depth; GR= Gingival Recession;
CAL= Clinical Attachment Level

 BaselinePost-OpChanges
Bone Level
from CEJ (MM)
7.02±2.764.06±1.702.56±2.29*
Defect Angle (°)27.54±11.9338.80±14.7811.26±9.29
(* P<0.05)


Sustained Release Throughout Resorption

Results: Total of 6 teeth currently analyzed. (n=6)
Clinical Parameters at Baseline and 6 Months. (Mean±SD)

 BaselinePost-OpChanges
PD (mm)7.67±1.123.44±0.734.22 ±0.97*
GR (mm)0.44±1.012.22±1.561.78±1.79*
CAL (mm)8.11±1.625.67±1.732.44±2.24*
(* P<0.05)
PD= Probing Depth;
GR= Gingival Recession;
CAL= Clinical Attachment Level

 BaselinePost-OpChanges
Bone Level
from CEJ (MM)
7.02±2.764.06±1.702.56±2.29*
Defect Angle (°)27.54±11.9338.80±14.7811.26±9.29
(* P<0.05)


The Most Versatile Shelf-Stable Regenerative Material Available

I would like to take this opportunity to thank Indiana University, Department of Periodontics for allowing residents to use BioXclude throughout residency and offering support to Snoasis Medical’s ongoing effort to document benefits provided by the use of amnion-chorion membrane in periodontal and dental implant surgery1,2,3.

Thank you for reading my latest update. I hope this new BioXclude 'Sandwich' Technique encourages you to "double your fun" while enabling you to better save your patient's natural detention.

References

1. Hassan M, Prakasam S. Intentional exposure of BioXclude amnion chorion allograft in ridge preservation of a heavy smoker: A case report. Snoasis Medical Report 2013

2. Hassan M, Prakasam S, et al. A randomized split-mouth clinical trial on effectiveness of amnion-chorion membranes in alveolar ridge preservation: A clinical, radiologic, and morphometric study. Int J Oral Maxillofac Implants 2017; 32:1389-1398.

3. Hamada Y, Chang J, Blanchard S. Novel Approach Utilizing Amnion-Chorion Membranes (BioXclude®) on the Root Surface for Regenerative Periodontal Procedures. Two Case Reports. Poster #77, American Academy of Periodontology Annual Meeting, September 9-12, 2017.

4. Current Poster. Hamada Y, Blanchard S. Amnion-Chorion Allograft Barrier Placed on Root Surface with Guided Tissue Regeneration for Periodontal Intrabony Defects. A Pilot Prospective Case Series. Poster #96, American Academy of Periodontology Annual Meeting, October 27-30, 2018.