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The Biology Behind BioXclude ®
The Biology Behind BioXclude®
The Biology Behind BioXclude ®

Infection Prevention
In addition to protecting the developing child from an attack from the mother’s immune system, the amnion-chorion membrane actively works to fight uterine infections that would pose a significant threat to the pregnancy.

“The chorion trophoblast layer is likely to have a particularly critical role in preventing infection ascending from the vagina crossing the fetal membranes and reaching the amniotic fluid and fetus.”
- King, et al., Placenta (2007) 28, p.161-169.

The trophoblast layer of the chorion is the outermost layer of the amniotic sac membrane. In addition to providing a physical barrier to infection, the trophoblast layer is loaded with beta-defensins, potent cysteine-rich peptides that fight bacterial, fungal, and viral infections.

Beta-defensins are short (18-45 a.a.), cysteine-rich peptides found in mucosal tissues, include the respiratory tract, reproductive tract, oral cavity, and placental tissues. The peptides are active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses.
© Adrei Lomize / Wikimedia Commons