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The Biology Behind BioXclude ®
The Biology Behind BioXclude®
The Biology Behind BioXclude ®


Active Growth Factors
NATURALLY BALANCED FOR GROWTH AND DEVELOPMENT
The amniotic sac must grow throughout pregnancy to accommodate the increasing size of the fetus. This requires active cellular proliferation and tissue generation, processes that are directed by growth factors in the tissue. High levels of growth factors are needed to keep the amnion-chorion growing at an appropriate rate throughout pregnancy. Over 200 soluble factors have been identified in dehydrated amnion-chorion allografts (MiMedx Primer, 2015), including key regulators of wound healing and tissue repair.


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Angiostatin
Galectin-7
TIMP-2
IL-1 F10
IGFBP-2
FLRG
IGFBP-6
Pentraxin 3
Resistin
CA9
OSM
TRAIL
Thrombos
WISIP-1
S100A8
RGM-B
Marapsin
PGRP-S
Thrombo
aFGF
FABP2
OPG
Trappin-2
Dkk-4
Lipocalin-2
Cystatin C
FGF-9
IL-1ra
Leptin
MCSF
Cripto-1
GASP-1
TFPI
GRO
GDNF
PIGF
Eotaxin-2
IGFBP-3
Thyroglobulin
OPN
Furin
DKK-1
GROa
PF4
BMP-5
Granulysin
Galectin-1
DAN
IL-21
Clusterin
MIF
GDF-15
CEA
MIP-1a
CXCL16
CNTF
TPO
Procalcitonin
sFRP-3
FGF-19
PDGF-AA
MCP-1
Kallikrein 5
PARC
FGF-21
VEGF
IP-10
NT-3
IL-18
IL-8
IL-1 F8
VEGF-D
I-309
Eotaxin
ACE-2
NSE
PAI-1
IL-1 F5
IL-1 F7
Gas 1
CRP
HGF
6Ckine
EG-VEGF
Cystatin B
CHI3L1
IL-17C
SP-D
uPA
ANG-4
Shh-N
TSH
Renin
NT-4
GASP-2
ANGPTL3
FGF-6
NAP-2
BDNF
ST2
IL-34
BAFF
EGF
GH
IGF-I
BTC
TGFb3
MIP-d
CK beta 8-1
IL-12p40
Adiponectin
TSP-1
Angioten
Serpin A4
Midkine
TGFb1
IL-1 F6
Dkk-3
IL-1 F9
Obsteoactivin
DcR3
Fractalkine
LAP(TGFb1)
IGF-2
DLL1
PDGF-88
Angiogenin
Cystatin A
BMP-7
MBL
Cystatin E M
NOV
Eotaxin-3
PDGF-AB
IL-33
SDF-1b
IL-6
BMP-9
LIGHT
TNFb
IL-1a
NRG1-b1
FGF-7
IL-32 alpha
IL-7
HB-EGF
Pref-1
Follistati
gp130
RBP4
hCGb
Legumain
Prolactin
bIG-H3
RANTES
WIF-1
Galectin-3
Follistatin
APRIL
Insulin
IL-24
CF XIV
ULBP-1
Chemerin
CSa
MIG
IL-23
IL-17B
VEGF-C
IL-6sR
MIP-1b
ENA-78
IL-20
TGFb2
Lymphotactin
AgRP
TNFa
I-TAC
Fit-3L
Il-1b
G-CSF
IL-2
Fetuin A
ANGPTL4
IGFBP-5
Adipsin
TIMP-1
LRIG3
IGFBP-1
BMP-2
HAI-2
CXCL14
IGFBP-4
FSH
TRANCE
TWEAK
Galectin-9
ADAMTS
ANG-2
MCP-2
IL-27
HCC-1
Kallikrein 14
bFGF
ANG-1
IL-16
IL-11
BLC
IL-17E
TIMP-4
IL-3
Galecin-2
SCF
GCP-2
GM-CSF
Activin A
IL-15
IL-4
Courtesy of MiMedx

Courtesy of MiMedx

When released from the amnion-chorion allograft, these factors have been shown to activate cells in vitro, indicating that they remain active the the Purion process and are available to stimulate cellular activity when placed into surgical treatment sites.


Courtesy of MiMedx

From the paper: “PURION® processed dHACM retains its biological activities related to wound healing, including the potential to positively affect four distinct and pivotal physiological processes intimately involved in wound healing: cell proliferation, inflammation, metalloproteinase activity and recruitment of progenitor cells.”

Purion processing maximizes the growth factor content in each allograft, delivering 20 times the growth factor load over amnion-only products produced with standard processing methods.


Courtesy of MiMedx


1. Koob, T.J. et al. (2013). Biological Properties of Dehydrated Human Amnion/Chorion Composite Graft: Implications for Chronic Wound Healing. International Wound Journal, 10 (5): 493–500.