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Does Your Membrane Have Antimicrobial Properties? BioXclude® Prevents Proliferation Of Oral Pathogens In-Vitro - New Publication

The oral cavity is arguably the most challenging environment for tissue regeneration in the body; it is relatively avascular and is filled with bacteria increasing the risk of infection at the surgical site, a complication that may lead to treatment failure.


BIOXCLUDE® SHOWN TO BE AS EFFECTIVE AS TETRACYCLINE
AGAINST THREE ORALLY RELEVANT BACTERIAL STRAINS IN VITRO
Bacteria thrive in warm, wet places, making the human mouth an ideal environment for bacterial colonization. Unsurprisingly, the oral microbiome contains hundreds of different strains of bacteria. Some strains are good while others are not. Known bad actors include the oral pathogens Aggregatibacter actinomycetemcomitans (A.a.), Streptococcus mutans (S.m.), and Streptococcus oralis (S.o.).


DOES YOUR MEMBRANE HAVE ANTIBACTERIAL PROPERTIES?

The inherent antibacterial properties within amniotic tissue are well-documented in literature.1,2,3 Until recently, however, there has not been published data specifically demonstrating the antimicrobial properties of Purion® processed BioXclude® dehydrated human deepithelialized amnion-chorion membrane (ddACM).

Today, I am pleased to share for the first time, and appearing in the International Journal of Dentistry, “Antimicrobial Activity of an Amnion-Chorion Membrane to Oral Microbes. CLICK TO VIEW PUBLICATION.



BIOXCLUDE IS THE ONLY OPTION WITH ANTIMICROBIAL PROPERTIES
In this study, ddACM (BioXclude) prevented growth of all three bacterial strains: A.a., S.m., and S.o., performing as well as Tetracycline in this assay. Conversely, porcine-derived collagen membrane (BioGide®) supported growth of bacterial strains.





While there are several barrier membrane options for hard and soft tissue regeneration, this independent published research further supports that BioXclude is the only option with antimicrobial properties.

I want to sincerely thank the University of Colorado Health Sciences, School of Dentistry, Department of Periodontics (Aurora, CO) for exposing residents to BioXclude during residency and making the membrane readily available in the clinic.





INDEPENDENT RESEARCH
I want to acknowledge and congratulate Drs. Haroon Ashraf, Kerri Font, and Charles Powell for their persistence in publishing this important independent research. It was no surprise that some reviewers simply did not believe the reported results - a membrane providing antimicrobial benefits!


Why Use Anything Else?
I strongly urge you to read this publication then ask yourself, why use anything other than BioXclude? The answer will justify the adoption of BioXclude in routine and challenging cases as an easy, impactful step to improve both practice productivity and patient satisfaction.





HELP SPREAD THE GOOD WORD ABOUT BIOXCLUDE
If you already use BioXclude every day, in most cases as a solo barrier, and sometimes with other membranes, please help spread the good word about BioXclude. Tell your colleagues and post cases on social media, #BioXclude. Thank You! I love good research so much that “Love Good Science and Research” is one of Snoasis Medical’s core values.

Warm Regards,
Snoasis Medical

Robert Tofe
President & Founder




REFERENCES
1) Yadav, K.Y. et al. (2017). Antimicrobial and Antibiofilm Effects of Human Amniotic/Chorionic Membrane Extract on Streptococcus pneumoniae. Frontiers in Microbiology. 8:1948. doi: 10.3389/fmicb.2017.01948.

2) Majid, A.B. et al. (2017). Antimicrobial Properties of Amniotic and Chorionic Membranes: A Comparative Study of Two Human Fetal Sacs. International Journal of Reproductive Infertility 18 (2): 218-224.

3) Noda-Nicolau, N.M. et al. (2017). Human Beta Defensins 1, 2 and 3 Produced by Amniochorion Membranes Is Similar in Term and Preterm Delivery. Open Journal of Obstetrics and Gynecology 07 (08): 846–57.