BioXclude is a minimally manipulated allograft amnion chorion tissue for use as a wound covering in dental surgery. Since its introduction in 2010, Snoasis Medical has distributed over 70,000 grafts of BioXclude. This allograft represents a paradigm shift in regenerative technology. Its unique physical and biological properties provide the benefits of a growth factor and an occlusive barrier.
Growth Factor Properties
BioXclude has been shown to contain over 250 biological factors, extracellular matrix (ECM) proteins, cytokines, interleukins, and tissue inhibitors of metalloproteinase (TIMP), known to play a role in wound healing and reducing inflammation1–4. In vitro, in vivo, and clinical research demonstrate the following benefits:1-3,5-9
- Rapid wound closure when left exposed
- Cellular occlusive with rapid sealing of protected space
- Hastens flap reattachment
- Allows for rapid vascular growth
- Shown to recruit mesenchymal stem cells
- Suppresses inflammation
Occlusive Barrier Properties
The physical properties of BioXclude allow clinicians to avoid many of the drawbacks associated with traditional collagen and synthetic membranes, which can help simplify the procedure, allow for less invasive surgery, and reduced chair time.5,7,10
The unique biologic and physical properties of amnion and amnion chorion (BioXclude) allograft allow it to be used as a wound covering for a multitude of dental implant / periodontal / oral maxillofacial applications which include5, 9, 11-17:
Sizing, Storage and Ordering
Using a larger piece makes placement much easier as it can fold over itself and/or multiple pieces overlap one another. The allograft also contains biological factors to aid healing. For these reasons, clinicians are encouraged to order larger sizes of BioXclude than they would when purchasing a traditional barrier membrane. BioXclude contains biological factors to aid healing. For this reason, and because it is thin, adaptable and excess material can be folded onto itself, clinicians are encouraged to use the entire piece, or in some cases, a bigger piece depending on the procedure. BioXclude is for single use only and is available in six sizes.
8mm x 8mm|
12mm x 12mm
10mm x 20mm
15mm x 20mm
15mm x 25mm
20mm x 30mm
|BioXclude is to be stored at ambient temperature. To place an order, please call Snoasis Medical at 1-866-521-8247 or download an order form by visiting the Order page of this website.|
References / Credits / Abbreviations
 Koob T, Rennert R, Zabek N, et al. Biological properties of dehydrated human amnion/chorion composite graft: implications for chronic wound healing. Int Wound J 2013: doi: 10.1111/iwj.12140.
 Koob T, Li W, Gurtner G et al. Angiogenic properties of dehydrated human amnion/chorion allografts: therapeutic potential for soft tissue repair and regeneration. Vas Cell 2014; 4(10): doi:10.1186/2045-824X-6-10.
 Koob T, Zabek N, Massee N, et al. Properties of dehydrated human amnion/chorion composite grafts: implications for wound repair and soft tissue regeneration. J BioMed Mat Res Part B 2014:00B:000-000.
 Xenoudi P, Lucas M, Chlipala E, et al. Comparison of porcine and amniotic resorbable collagen membranes using H&E staining and immunohistochemistry. Manuscript in Preparation. Data on file at Snoasis Medical.
 Holtzclaw D, Toscano N. Amnion chorion allograft barrier: indications and techniques update. J Imp Adv Clin Dent 2012; 4(2):25-38.
 Holtzclaw D, Toscano N. BioXclude™ placental allograft tissue membrane in combination with bone allograft for site preservation: A Case Series. J Imp Adv Clin Dent 2011; 3(3):35-50.
 Wallace W, Cobb C. histological and computed tomography analysis of amnion chorion membrane in guided bone regeneration in socket augmentation. J Imp Adv Clin Dent 2011; 3(6): 61-72.
 Holtzclaw D, Hinze F, Toscano N. Gingival flap attachment healing with amnion-chorion allograft membrane: A controlled, split mouth case report replication of the classic 1968 Hiatt study. J Imp Adv Clin Dent 2012; 4(5):19-25.
 Holtzclaw D, Toscano N. Amnion–chorion allograft barrier used for guided tissue regeneration treatment of periodontal intrabony defects: A retrospective observational report of 64 patients. Clin Adv Perio 2013; 3(3):131- 137.
 BioXclude Handling Instructions, PR091301v04. Data on File at Snoasis Medical.
 Holtzclaw D, Cobb C. Extraction site preservation using new graft material that combines mineralized and demineralized allograft bone: a case series report with histology. Compendium. Feb 2014; 107-112.
 Niknejad H, Peirovi H, Jorjani M, et al. Properties of the amniotic membrane for potential use in tissue engineering. Euro Cells Mat 2008; 15: 88-89.
 Kesting M, Wolff KD, Nobis C, et al. Amniotic membrane in oral and maxillofacial surgery. Oral Maxillofac Surg 2012; Epub Dec 16.
[A] Dan Holtzclaw, DDS, MS, Austin, TX
[B] Robert J Miller, DMD, Plantation, FL
[ECM] Extracellular Matrix
[PDGFα] Platelet-Derived Growth Factor-Alpha
[PDGFβ] Platelet-Derived Growth Factor-Beta
[TGFβ] Transforming Growth Factor-Beta
[bFGF] Basic Fibroblast Growth Factor
[EGF] Epidermal Growth Factor
[IL-1ra] Interleukin-1 Receptor Antagonist
[VEGF] Vascular Endothelial Growth Factor
[GCSF] Granulocyte-Colony Stimulating Factor
[PLGF] Placenta Growth Factor
[TIMP] Tissue Inhibitor of Metalloproteinase
[Maxxeus 70/30] Maxxeus cortical mineralized / demineralized allograft bone 70/30 blend (Community Tissue Services, Dayton, OH)